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KMID : 0352119950110030273
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Journal of Kyung Hee University
1995 Volume.11 No. 3 p.273 ~ p.280
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Treatment of Advanced Gastric Cancer with 5-Fluorouracil, Etoposide, and Cisplatin(FEP)
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최환석
박지훈/현용준/김정희/김시영/윤휘중/조경삼
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Abstract
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We conducted a Phase II trial of 5-fluorouracil, etoposide, and cisplatin (FEP) in previously untreated or treated patients with metastatic or recurrent gastric adenocarcinoma. From August 1993 to February 1995, 22 patients were enrolled in this
study.
The treatment regimen consisted of 12 hours continuous intravenous infusion of 5-fluorouracil (800 mg/㎡/day) on day 2 to day 4, bolus IV of etoposide (100 mg/㎡/day) on day 2 to day 4, and cisplatin (60 mg/㎡/day) on day 1. Eighteen patients
were
evaluable. There were no patients showing major response and only one patient achieved minimal improvement. The median overall survival was 112 days (17~462+days). Toxicities more than grade III included neutropenia (21.6%), thrombocytopenia
(9.7%),
nausea, and vomiting (4.0%).
In conclusion. FEP regimen is relatively tolerable but these regimen has a low antitumor activity in terms of response rate and overall survival rate in patients with advanced gastric cancer
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KEYWORD
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